期刊
TETRAHEDRON
卷 68, 期 38, 页码 8046-8051出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.06.073
关键词
5-Iminooxazolines; alpha-Amidoacrylates; Cyclohexyl isocyanide; [4+1] Cycloaddition; Solvent-free synthesis
A novel atom economical diastereoselective synthesis of 5-iminooxazolines and their subsequent transformation to alpha,alpha-disubstituted dipeptide esters is described. Heating a mixture of cyclohexyl isocyanide and Z-alpha-benzoyl amino-acrylic acid alkyl esters under solvent-free conditions, afforded 5-iminooxazolines, which, upon specifications provided alpha,alpha-disubstituted dipeptide esters in good yield. (C) 2012 Elsevier Ltd. All rights reserved.
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