期刊
TETRAHEDRON
卷 67, 期 24, 页码 4435-4441出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.02.027
关键词
Alkenes; Asymmetric catalysis; Hydroarylation; Palladium-catalyzed
资金
- NIGMS NIH HHS [R01 GM063540-09, R01 GM063540-07S2, R01 GM063540-08, R01 GM063540] Funding Source: Medline
Alkenes are desirable and highly versatile starting materials for organic transformations, and well-known substrates for palladium catalysis. Typically, these reactions result in the formation of a new alkene product via beta-hydride elimination. In contrast to this scenario, our laboratory has been involved in the development of alkene hydro- and difunctionalization reactions, where beta-hydride elimination can be controlled. We report herein the development of an asymmetric palladium-catalyzed hydroarylation, which yields diarylmethine products in up to 75% ee. Interestingly, a linear free energy relationship is observed between the steric bulk of the ligand within a certain range and the ee of the reaction. (C) 2011 Elsevier Ltd. All rights reserved.
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