期刊
TETRAHEDRON
卷 67, 期 35, 页码 6679-6681出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.04.098
关键词
Pyridoacridine; Sponge; Isolation; NMR; Cell differentiation
资金
- MEXT
- Grants-in-Aid for Scientific Research [23770081] Funding Source: KAKEN
Two pyridoacridines closely related to the known isocystodamine were isolated from the marine sponge Biemna sp. together with isocystodamine. Their structures were determined on the basis of spectroscopic data. They induce the erythroid differentiation of human leukemia K562 cells with an ED(50) value of 5 nM each. (C) 2011 Elsevier Ltd. All rights reserved.
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