期刊
TETRAHEDRON
卷 67, 期 38, 页码 7294-7300出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.07.052
关键词
Indolo[1,2-a]quinoxalinones; CuI/t-Proline catalyst; Ugi reaction; Ullmann reaction; One-pot procedure
资金
- Alexander von Humboldt foundation
- Kimia Exir Company
An efficient strategy for the one-pot syntheses of indolo[1,2-a]quinoxalinones catalyzed by CuI have been developed. The procedures combine the Ugi four-component reaction of aldehydes, 2-iodoaniline, 2-indole carboxylic acid, and isocyanides followed by the copper-catalyzed intramolecular N-arylation of the Ugi product in one-pot procedure, which afford the desired products in good to very good yields. (C) 2011 Elsevier Ltd. All rights reserved.
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