期刊
TETRAHEDRON
卷 67, 期 26, 页码 4933-4938出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.04.079
关键词
Palladium-catalyzed reaction; Heterocycles; Cinnoline; Annulation; 2-Iodotriazene
资金
- Nanyang Technological University
A simple and efficient synthesis of cinnolines was achieved by a palladium-catalyzed annulation methodology. 3,4-Disubstituted cinnolines are prepared via palladium-catalyzed annulation of 2-iodophenyltriazenes with an internal alkyne in moderate to good yields. Several internal alkynes are applicable to this reaction and it is compatible with a number of functional groups. (C) 2011 Published by Elsevier Ltd.
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