期刊
TETRAHEDRON
卷 67, 期 11, 页码 2066-2071出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.01.050
关键词
Oxidation; 2-Oxazolines; Oxazoles; Dioxygen; Environmental-benign
资金
- State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences) [SIMM090104-KF-04]
- National Natural Science Foundation [20902111]
- Program for New Century Excellent Talents in University (NCET)
- Ministry of Education of China
- Fundamental Research Funds [JKZ2009002, JKY2009013]
A facile and environment-benign oxidation by dioxygen as the sole oxidant was applied for the conversion of 2-oxazolines to oxazoles. The substituent effect on 2-oxazoline ring was investigated. The use of this methodology for the synthesis of a key intermediate of a CDC25 phosphatase inhibitor (SC-alpha alpha delta 9) as an anticancer agent was also described. (C) 2011 Elsevier Ltd. All rights reserved.
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