Total synthesis of (±)-hyrtiazepine

The total synthesis of the azepinoindole alkaloid, (+/-)-hyrtiazepine, was achieved. Construction of the azepinoindole core structure was carried out by C-4 selective alpha-hydroxyalkylation of 5-hydroxyindole, introduction of serine at C-3 of the indole moiety, and intramolecular imination. (C) 2011 Elsevier Ltd. All rights reserved.