期刊
TETRAHEDRON
卷 67, 期 49, 页码 9522-9528出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.10.005
关键词
Multicomponent reactions; Heterocycles; Pyridine; Thiazoline; Knoevenagel reaction; Nitrile
资金
- Abant Izzet Baysal University, Directorate of Research Projects Commission [2011.03.03.391]
A series of thiazolo[3,2-a]pyridines have been prepared using a multicomponent reaction between aromatic aldehydes, 2-nitromethylenethiazolidine and nitriles containing an active methylene group (malononitrile, ethyl 2-cyanoacetate and 2-phenylsulfonylacetonitrile) in the presence of Et3N under mild conditions with high yields. One of the compounds shows promising anticancer activity across a range of cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved.
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