期刊
TETRAHEDRON
卷 67, 期 40, 页码 7780-7786出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.07.077
关键词
Marine compounds; Cyclic peptides; Theonella swinhoei; Anti-Inflammatory activity
资金
- Generalitat Valenciana [BFPI/2009/145]
- Spanish Ministry of Science and Innovation [SAF2009-10347]
Two new cyclopeptides, perthamides E and F were isolated from the polar extracts of the sponge Theonella swinhoei. The new structures, featuring an unprecedented beta-amino acid unit (AHMOA), were determined by interpretation of NMR and MS data. The absolute configuration of the AHMOA residue was proposed on the basis of quantum chemical calculation of NMR chemical shifts. Perthamides were proved to inhibit TNF-alpha and IL-8 release in primary human keratinocytes cells and therefore could represent potentially leads for the treatment of psoriasis. (C) 2011 Elsevier Ltd. All rights reserved.
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