期刊
TETRAHEDRON
卷 67, 期 52, 页码 10261-10266出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.10.028
关键词
Cyclopamine; Steroidal alkaloid; Cancer chemotherapy; Hedgehog signaling; Structure-activity relationships
资金
- NIH [CA-134983]
The design, synthesis, and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a hedgehog signaling inhibitor, are described. Structure-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents. (C) 2011 Elsevier Ltd. All rights reserved.
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