4.4 Article

I-MCR-Ullmann cascade toward furo[2,3-b]indole scaffold

期刊

TETRAHEDRON
卷 67, 期 34, 页码 6375-6381

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.05.101

关键词

Copper catalysis; Furan; Indole; Intramolecular Ullmann coupling; Isocyanide-based multicomponent reaction (I-MCR); One-pot reaction

资金

  1. National Natural Science Foundation of China [20672079, 20910102041, 21042007]
  2. Nature Science Basic Research of Jiangsu Province for Higher Education [10KJB150016]
  3. Soochow University

向作者/读者索取更多资源

An efficient method for the construction of furo[2,3-b]indole derivatives 5 via an isocyanide-based multicomponent reaction (I-MCR) and a copper-catalyzed intramolecular Ullmann reaction sequence was described. This two-step sequence can be performed in a one-pot manner to produce the desired product 5 in moderate to good yield (up to 90%). (C) 2011 Published by Elsevier Ltd.

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