期刊
TETRAHEDRON
卷 67, 期 26, 页码 4758-4766出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.05.034
关键词
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资金
- Program for Promotion of Basic and Applied Research for Innovation in the Bio-oriented Industry (BRAIN)
- Grants-in-Aid for Scientific Research [23390026] Funding Source: KAKEN
The second-generation enantioselective synthesis of heliannuol A and the first enantioselective total synthesis of heliannuol K (via two routes) have both been accomplished efficiently; (heliannuol A, nine steps and 25% yield; heliannuol K, seven steps and 47% yield). Highlights of our synthetic strategy include a substrate-controlled chirality transfer in the Lewis acid mediated Claisen rearrangement of the allyl aryl ether for the key construction of a tertiary stereogenic center at the benzylic position followed by, for heliannuol A, ring-closing metathesis, diastereoselective epoxidation, and regioselective cleavage of the epoxide; and for heliannuol K, ring-closing metathesis and conjugate reduction of the eight-membered enone. (C) 2011 Elsevier Ltd. All rights reserved.
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