期刊
TETRAHEDRON
卷 67, 期 25, 页码 4498-4504出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.04.105
关键词
Kadsura ananosma; Dibenzocyclooctadiene lignans; Ananonins; Neuroprotective effect
资金
- NSFC [30830115, 20902093]
- Science and Technology Program of Yunnan Province [2008GA031]
- Major State Basic Research Development Program of China [2009CB522300, 200940900]
- Western Doctoral Foundation of Chinese Academy of Sciences
- CAS [KZCX2-XB2-15]
- National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program of China' [2009ZX09301-001, 063]
Fourteen new dibenzocyclooctadiene lignans, ananonins A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of MS, NMR, and CD techniques. The biological activity of these compounds was evaluated, and ananonin M (13) showed moderate neuroprotective effects in an in vitro assay. (C) 2011 Elsevier Ltd. All rights reserved.
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