期刊
TETRAHEDRON
卷 67, 期 6, 页码 1245-1250出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.11.087
关键词
Dichotella gemmacea; Gorgonian; Iodine-containing briarane type diterpenoid; Dichotellides; X-ray diffraction; Cytotoxicity
资金
- National Natural Science Foundation of China [40706046, 30973679, 20902094]
- National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
- Chinese Academy of Science [LYQY200703, SQ200904, KSCX2-EW-G-12B, KSCX2-YW-G-073]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry
- LMB Foundation [091002]
Five new briarane type diterpenoids, dichotellides A-E (1-5), were isolated from the South China Sea gorgonian Dichotella gemmacea together with four known analogues (6-9). Compounds 1-5 represent the first examples of iodine-containing briarane type diterpenoids from nature. The structures of these diterpenoids were elucidated by spectroscopic analysis, including 1D, 2D-NMR, and HRESIMS, and the absolute configuration of 1 was further confirmed by single crystal X-ray diffraction analysis. All the isolates were evaluated for cytotoxicity activity against four human tumor cell lines, and only 3 exhibited marginal activity against SW1990 (human pancreatic cancer). (C) 2010 Elsevier Ltd. All rights reserved.
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