An efficient and stereoselective cycloaddition of C-aryl and C-amido nitrones to dimethyl 2-benzylidenecyclopropane-1,1-dicarboxylate

1,3-Dipolar cycloalditions of dimethyl 2-benzylidenecyclopropane-1,1-dicarboxylate and a number of C-aryl or C-amido nitrones proceed with high efficiency and selectivity with the formation of only one isomeric spiral[cyclopropane-1,4-isoxazolidine] cycloadduct. (C) 2011 Elsevier Ltd. All rights reserved.