期刊
TETRAHEDRON
卷 67, 期 23, 页码 4185-4191出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.04.064
关键词
Palladium; Phenylglycine; Carbonylation; Isoindolones; Hydrogenation
资金
- Spanish Ministerio de Ciencia e Innovacion [CTQ2008-01784, CTQ2010-17436]
- Gobierno de Aragon [PI071/09, E21, E40]
- CSIC (Spain)
The orthopalladation of methyl arylglycinate derivatives has been studied. The reaction proceeds efficiently for different electron-withdrawing and electron-releasing substituents at the aryl ring. The carbonylation of the orthopalladated complexes affords, in a single step, substituted (1H)-isoindolin-1-one-3-carboxylates. These compounds constitute valuable synthetic intermediates and can be transformed diastereoselectively into octahydroisoindole-1-carboxylic acid derivatives, an important scaffold in the synthesis of many biologically active compounds. (C) 2011 Elsevier Ltd. All rights reserved.
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