期刊
TETRAHEDRON
卷 67, 期 16, 页码 2969-2973出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.02.044
关键词
Tandem reaction; Internal alkynes; Annulation; Palladium catalysis
资金
- National Natural Science Foundation of China [20772114]
- Innovation Fund for Outstanding Scholar of Henan Province [621001100]
An efficient and facile synthesis of isoquinolines has been described via a tandem reaction of imination of o-halobenzaldehydes with tert-butyl amine and subsequent palladacycle-catalyzed iminoannulation of internal alkynes. This tandem reaction could be carried out successively in one pot without any special operation, and the annulation step could afford isoquinolines derivatives in moderate to good yields with high regioselectivity. In addition, the simple synthesis of indoles was realized by palladacycle-catalyzed annulation of o-iodoaniline or o-bromoanilines with internal alkynes. (C) 2011 Elsevier Ltd. All rights reserved.
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