期刊
TETRAHEDRON
卷 66, 期 12, 页码 2111-2118出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.12.022
关键词
-
资金
- NIH [P01 CA 92537, R01 CA 039504, R01 ES 015857, P30 ES 013508]
The hypervalent iodine reagents o-iodoxybenzoic acid (IBX) and bis(trifluoro-acetoxy)iodobenzene (BTI) at e shown to be general reagents for regio-controlled oxidation of polycyclic aromatic phenols (PAPs) to specific isomers (ortho. para. or remote) of polycyclic aromatic quinones (PAQs). The oxidations of a series of PAPs with IBX take place under mild conditions to furnish the cot responding ortho-PAQs In contrast, oxidations of the same series of PAPs with BTI exhibit variable regiospecificity. affording para-PAQs where Structurally feasible and ortho-PAQs or remote PAQ isomers in other cases The structures of the specific PAQ isomers formed are predictable oil the basis of the inherent regioselectivities of the hypervalent iodine reagents in combination with the structural requirements of the phenol precursors IBX and BTI are recommended as the preferred reagents for regio-controlled oxidation of PAPs to PAQs (C) 2009 Published by Elsevier Ltd
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