期刊
TETRAHEDRON
卷 66, 期 31, 页码 5801-5810出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.05.005
关键词
Metal-free; Hypervalent iodine; Cyclopropanation; Cyclopropyl keto-esters; Iodonium ylide
资金
- KYTHERA Biopharmaceuticals, Inc. Calabasas, California
Intramolecular cyclopropanation of alkenes occurs thermally with iodonium ylides in the absence of conventional metal catalysts such as Rh(II) and Cu(II). In rigid molecular systems conversions are near quantitative. A mechanism is proposed involving formal 2+2 cycloaddition followed by reductive elimination of PhI to yield the cyclopropane. (C) 2010 Elsevier Ltd. All rights reserved.
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