期刊
TETRAHEDRON
卷 66, 期 2, 页码 494-497出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.11.063
关键词
1,2,4-Oxadiazole; Amidoxime; Nitrile; Potassium fluoride; Solvent free
资金
- Research Council of K.N. Toosi University of Technology
Potassium fluoride was found to be an efficient catalyst and solid support for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. in this work, a one-pot method for the synthesis of these compounds from the reaction of nitriles with hydroxylamine hydrochloride and acyl chloride in the presence of potassium fluoride under solvent-free conditions using microwave irradiation has been developed. The advantages of using potassium fluoride as a solid support in comparison to conventional solid supports are simple operation and convenient separation of the products. (C) 2009 Elsevier Ltd. All rights reserved.
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