期刊
TETRAHEDRON
卷 66, 期 33, 页码 6445-6449出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.04.092
关键词
Flow chemistry; Domino reactions; Spiropiperidines; Olefination reactions; 1,3-Dipolar cycloaddition
A domino cyclization reaction of the bis-unsaturated ketone 3 with hydroxylamine proceeds with good yield and high stereoselectivity, in a flow reactor system. The tricyclic spiropiperidine products 5 and 2 obtained are valuable building blocks for the synthesis of analogues of the histrionicotoxin alkaloids. (C) 2010 Elsevier Ltd. All rights reserved.
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