期刊
TETRAHEDRON
卷 66, 期 34, 页码 6718-6724出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.06.082
关键词
Isoselenocyanates; Peptidomimetics; Selenoureas; Selenoureidopeptidomimetics
资金
- Department of Science and Technology [lSR/S1/OC-26/2008]
- Council of Scientific and Industrial Research, Govt. of India [01(2323)/09/EMR-II]
- Bangalore University, Bangalore
- CSIR, Govt. of India
Isoselenocyanates derived from Boc/Z-amino acids are prepared by the reaction of the corresponding isonitriles with selenium powder in presence of triethylamine at reflux. The utility of these new classes of isoselenocyanates in the preparation of selenoureidodipeptidomimetics possessing both amino as well as carboxy termini has been accomplished. The H-1 NMR analysis confirmed that the protocol involving the conversion of isonitriles to isoselenocyanates and their use as coupling agents in assembling selenour-eido derivatives is free from racemization. (C) 2010 Elsevier Ltd. All rights reserved.
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