Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities

Three novel carbon-bridged citrinin dimers dicitrinones A-C (1-3) were Isolated from a volcano ash-derived fungus Penicillium citrinum Their structures were elucidated by spectroscopic methods Dicitrinone A (1) and B (2) are two atropisomeric mixtures which were verified by both NMR and quantum chemical calculations Their cytotoxicity against four tumor cell lines (HL-60 MOLT-4 A-549 and BEL-7402) was evaluated by SRB and mu methods Dicitrinone B (2) arrested the HL-60 cell cycle at the G2/M phase which was analyzed using flow cytometry (C) 2010 Elsevier Ltd All rights reserved