期刊
TETRAHEDRON
卷 66, 期 11, 页码 2026-2036出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.01.043
关键词
Pavettamine; Gousiekte; Stereoselective synthesis; Polyamine; Pavetta harborii; beta-Ketosulfoxide reduction
资金
- Agricultural Research Council (ARC-OVI)
- University of Pretoria
- CSIR
- Gauteng and North-West Province Departments of Agriculture
The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the (13)C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol. (C) 2010 Elsevier Ltd. All rights reserved.
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