期刊
TETRAHEDRON
卷 66, 期 29, 页码 5459-5466出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.05.023
关键词
L-Glutamic acid; Crystal polymorphism; 'Tailor-made' Additives
资金
- Irish Research Council of Science, Engineering and Technology
Poly-N-5-acrylamidoisophthalic acid (4), poly-N-(5-(N'-(3,5-dicarboxyphenyl)carbamoyl)pentyl)acrylamide (10a) and poly-N-(11-(N'-(3,5-dicarboxyphenyl)carbamoyl)undecyl)acrylamide (10b) were prepared and assessed as polymorph-selective crystallization inhibitors of the stable beta form of L-glutamic acid. Polymerization was carried out as the final step in the preparation of 10a and 10b to ensure the preparation of fully functionalized polymers. Polymers 4, 10a and 10b were effective as complete inhibitors of the stable beta form of L-glutamic acid in quantities of 0.5% w/w or greater, whereas the corresponding 'monomeric' additives 2 and 11 required quantities of 3% or greater to completely inhibit the beta form, demonstrating a cooperative binding effect by the polymeric additives. Within the series of polymers 4, 10a and 10b, polymer 10a, which features a short tethering chain, was the most effective. (C) 2010 Elsevier Ltd. All rights reserved.
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