期刊
TETRAHEDRON
卷 66, 期 27-28, 页码 5082-5088出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.04.115
关键词
Organocatalysis; Ionic liquids; Amino acids; Asymmetric synthesis; Aldol reaction
资金
- Deutsche Forschungsgemeinschaft (DFG)
New amino acid-1,2,3-triazolium conjugates were synthesized by establishing a 1,2,3-triazolium unit to the amino acid through Cu-catalyzed alkyne-azide cycloaddition and subsequent N-methylation. These products were applied as ionic-liquid-tagged organocatalysts in asymmetric direct aldol reactions. Remarkably, a lysine-derived conjugate performed better than proline derivatives. Evidence was found that IL-tagging improved the catalytic performance. Recycling of the organocatalyst was easily possible by extraction of products. (C) 2010 Elsevier Ltd. All rights reserved.
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