期刊
TETRAHEDRON
卷 66, 期 20, 页码 3593-3598出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.03.031
关键词
Allylic alkylation; D-2-Symmetry; Phosphoramidite ligand; Grignard reagent
资金
- National Natural Science Foundation of China [20972095]
- Science and Technology Commission of Shanghai Municipality [09JC1407800]
- Nippon Chemical Industrial Co., Ltd
A novel class of atropos dibridged biphenyl phosphoramidites bearing a D-2-symmetric biphenyl backbone was prepared and applied as chiral ligands in the copper-catalyzed allylic alkylation with Grignard reagent. The alkylation products were obtained in quantitative yields with high regioselectivities up to 94:6 of S(N)2'/S(N)2 ratio and enantiomeric excesses up to 91.1% for S(N)2' products. The unique D-2-symmetric backbone ligands have the advantages of easy preparation and sufficient reusability of their key intermediates from the undesired isomers. (C) 2010 Elsevier Ltd. All rights reserved.
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