期刊
TETRAHEDRON
卷 66, 期 19, 页码 3441-3446出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.03.033
关键词
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资金
- FAPESP [07/02382-7]
- CNPq [472064/2008-8]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [07/02382-7] Funding Source: FAPESP
The synthesis of selenium derivatives of naturally occurring chiral molecules is becoming increasingly important in recent years. In this context, we describe herein an easy, straightforward synthetic route for the preparation of a series of chiral seleno-furanosides, starting from the readily available carbohydrate D-xylose. In addition, selected compounds were screened as inhibitors of the delta-aminolevulinate dehyclratase (delta-ALA-D) enzyme. Diselenide 4 was found to reduce significantly the enzymatic activity, while seleno-furanoside la increased delta-ALA-D activity. (C) 2010 Elsevier Ltd. All rights reserved.
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