期刊
TETRAHEDRON
卷 65, 期 48, 页码 10069-10073出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.09.081
关键词
3-Cyanomethylidene oxindole; DBU; Azaenamines; Michael addition; Spiropyridazines
资金
- Alexander von Humboldt Foundation, Germany
3-Cyanomethylidene oxindole derivatives were prepared in excellent yields utilizing DBU-promoted Knoevenagel condensation of isatin derivatives with active methylene reagents. The isolated products were then reacted with azaenamines via a DBU-promoted Michael addition to yield spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and their fused derivatives. (C) 2009 Elsevier Ltd. All rights reserved.
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