期刊
TETRAHEDRON
卷 65, 期 6, 页码 1147-1152出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.11.068
关键词
Harrisotones A-E; Harrisonol A; Cytotoxic activity; Structural elucidation; Harrisonia perforata
资金
- National Natural Science Foundation [30630072, 30721005]
Five novel prenylated polyketides, harrisotones A-E (1-5) representing a rare spirocyclic skeleton, along with a new hydroperoxypolyketide harrisonol A (6), were isolated from the stems and leaves of Harrisonia perforata. The structures of harrisotones A-E (1-5) were extensively elucidated on the basis of spectroscopic analysis, especially 2D NMR and CD spectra. A plausible origin of compounds 1-5 was rationalized biogenetically, and traced back to harrisonol A (6). Harrisotones A-C (1-3) and harrisonol A (6) exhibited significant cytotoxicity against P-388 and/or A-549 tumor cell lines. (C) 2008 Elsevier Ltd. All rights reserved.
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