期刊
TETRAHEDRON
卷 65, 期 8, 页码 1593-1598出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.12.063
关键词
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资金
- MCPT
- NEDO
- JSPS
- MEXT Japan
The Barton reaction (nitrite photolysis) of a steroidal substrate 1, to give 2, a key intermediate for the synthesis of myriceric acid A, an endothelin receptor antagonist, was successfully carried out in a continuous microflow system using a Pyrex glass-covered stainless-steel microreactor having a one lane microchannel (Type A: 1000 mu m width, 107 mu m depth, 2.2 m length). We found that using a low-power black light (peak wavelength: 352 nm) and UV-LED light (peak wavelength: 365 nm) as the light source will suffice for the Barton reaction, creating a compact energy-saving photo-microreaction system. A multi-gram-scale production was attained using a multi-lane microreactor (Type B: 1000 mu m width, 500 mu m depth, 0.5 m length, 16 lanes) in conjunction with a black light. (C) 2008 Published by Elsevier Ltd.
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