期刊
TETRAHEDRON
卷 65, 期 7, 页码 1241-1246出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.12.020
关键词
-
资金
- National Institute of Health [RO3 EY13941-01]
- NMR
A redox- and light-sensitive, T-1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r(1) relaxivity of 2.51 m M (1)s (1) (60 MHz, 37 C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r(1) relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH. (C) 2008 Elsevier Ltd. All rights reserved.
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