期刊
TETRAHEDRON
卷 65, 期 46, 页码 9598-9603出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.09.056
关键词
Polysulfur alkaloid; Tunicate; Structure assignment; Cytotoxicity; L1210; V79
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [18032033, 21603012, 17035029]
- Grants-in-Aid for Scientific Research [17035029, 21603012] Funding Source: KAKEN
Seven new polysulfur alkaloids, lissoclibadins 8 (1)-14 (7), were isolated from an ascidian, Lissoclinum cf. badium, collected in Indonesia. The structures were assigned on the basis of their spectroscopic data and computational modeling study. Lissoclibadin 8 (1) had four identical dopamine-derived units, and this is the first instance of a tetramer. Lissoclibadin 9 (2) was the second example of trimers next to lissoclibadin 1 (8). Lissoclibadins 10 (3)-12 (5) were symmetric dimers, and 13 (6) had a dopamine and ethyl units connected by sulfide and disulfide bonds. Lissoclibadin 14 (7) was a varacin type monomer. These compounds inhibited the colony formation of Chinese hamster V79 cells and cell proliferation of murine leukemia L1210 cells. (C) 2009 Elsevier Ltd. All rights reserved
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