期刊
TETRAHEDRON
卷 65, 期 29-30, 页码 5669-5675出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.05.039
关键词
beta-Peptides; Crystal structure; Hydrogen bonds; Cyclobutanes
资金
- Ministerio de Educacion y Ciencia (MEC) [CFQ2006-01080, CrQ2007-61704/BQU]
- Generalitat de Catalunya [GQ (2005SGR-103]
The synthesis of some representative compounds of a new class of cyclobutane-containing beta-peptides starting from (-)-verbenone as a chiral precursor is presented. In these products, the cyclobutane moiety is not a part of the peptide backbone but a bulky substituent at the beta(3)-position. These compounds have been carefully characterized and studied on the basis of the combined use of several experimental techniques together with molecular modeling by means of theoretical calculations. In the solid state, the non-cyclic beta-peptides adopt a hairpin-like molecular folding ruled by intermolecular hydrogen bonds in the crystal packing. (C) 2009 Elsevier Ltd. All rights reserved.
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