期刊
TETRAHEDRON
卷 65, 期 26, 页码 4957-4967出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.03.103
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资金
- NIH [GM-079339]
- Boehringer-Ingelheim
- Bristol Myers Squibb
- Eli Lilly
- Packard Foundation
- Beckman Foundation
- Sloan Foundation
An N-heterocyclic carbene (NHC) catalyzed intramolecular lactonization to prepare densely functionalized bicyclic gamma-lactam-gamma-lactone adducts from enals is reported. This method has been applied to the formal synthesis of salinosporamide A, a potent 20S proteasome inhibitor and anti-cancer therapeutic. (C) 2009 Elsevier Ltd. All rights reserved.
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