期刊
TETRAHEDRON
卷 65, 期 34, 页码 6953-6958出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.06.054
关键词
Phomallenic acid C; Inhibitor of FAS II pathway; anti-S(N)2 ' Coupling; Ohrui-Akasaka method; Organoindium
Enantioselective synthesis of phomallenic acid C, an inhibitor of bacterial FAS II pathway, was succeeded. Allenyldiyne structure was constructed by a direct anti-S(N)2' Coupling of propargyl mesylate with diynylindium in the presence of palladium catalyst. Enantiomeric purity was determined by Ohrui-Akasaka method to be 96% ee. (C) 2009 Elsevier Ltd. All rights reserved.
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