期刊
TETRAHEDRON
卷 65, 期 21, 页码 4085-4091出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.03.064
关键词
Alkynylation; Cross-coupling; Deoxyadenosine; Nucleosides; Sonogashira
资金
- Grand Valley State University
- Chemistry Department at GVSU
- Weldon Fund
The Sonogashira cross-coupling reaction offers a convenient route to C(sp)C(sp(2)) bond formation. Although the Sonogashira reaction has traditionally been carried out in the presence of Pd catalyst and a co-catalyst of Cu(I) salt, the use of Cu(I) salt is often not efficient because it leads to the formation of unwanted side-products. This has prompted interest in recent years in the development of Cu-free Sonogashira cross-coupling reaction conditions. In addition, the development of Cu-free Sonogashira cross-coupling conditions for the alkynylation of nucleoside derivatives remains largely unexplored. Herein, we demonstrate that Cu- and amine-free Sonogashira-type cross-coupling lead to successful alkynylation of aryl bromides and heteroaryl bromides. For the first time, we have extended this method for the alkynylation of protected 2'-deoxyadenosine at the C-6 position. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据