期刊
TETRAHEDRON
卷 65, 期 40, 页码 8378-8383出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.08.007
关键词
Nicotinamide adenine dinucleotide; Coupling reaction; Phosphodiesters; Bioorganic chemistry
资金
- National Natural Science Foundation of China [20472084]
Fourteen phosphodiester-type beta-nicotinamide adenine dinucleotide (NAD+) analogs were prepared starting from nicotinamide. The phosphodiester linkage was effectively assembled in 69-93% yields via condensation reaction between 2'.3'-di-O-acetyl nicotinamide mononucleotide and alcohols in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride. The analog beta-nicotinamide ribose-5-(2-phenylethyl) phosphate showed beneficial effects on cell growth of model microorganisms. (C) 2009 Elsevier Ltd. All rights reserved.
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