Hydroalkylation leading to heterocyclic compounds (Part 2): practical synthesis of polysubstituted 1,2,3,4-tetrahydropyridines through multicomponent reactions (MCRs)

Polysubstituted 1,2,3,4-tetrahydropyridines were synthesized through hydroalkylation of electron-deficient alkynes, followed by double Mannich addition reactions, which is a practical protocol with atom efficiency and good substrate scope. (C) 2009 Elsevier Ltd. All rights reserved.