期刊
TETRAHEDRON
卷 65, 期 33, 页码 6720-6729出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.03.011
关键词
Oxidative; Rearrangement; Furanyl carbamate; Lithiate; Addition; 2,4-Disubstituted pyrrole
资金
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0742663] Funding Source: National Science Foundation
An efficient approach to 2,4-disubstituted pyrroles has been uncovered and is based on an oxidative rearrangement of a furanyl carbamate followed by sequential reaction of the resulting 5-methoxypyrrol-2(5H)-one with various alkyl lithiates. The final step of the procedure involves heating the ring opened 1-methoxy-5-oxopentylcarbamate with a primary amine. The overall process can be carried out under mild conditions and complements existing methods to prepare 2,4-disubstituted pyrroles. (C) 2009 Elsevier Ltd. All rights reserved.
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