期刊
TETRAHEDRON
卷 65, 期 41, 页码 8513-8523出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.08.019
关键词
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资金
- Ministry of Health [NR/9138-3]
- Ministry of Education [21306065, LC06077, LC06061]
- Czech Science Foundation [203/09/0820, 240550506]
Novel reagents for the synthesis of 1-substituted uracil and thymine derivatives have been developed. The aminolysis of 2- or 4-nitrophenyl 3-ethoxyacryloylcarbamate and 3-ethoxy-2-methylacryloylcarbamate with a variety of primary amino derivatives proceeded smoothly under very mild reaction conditions yielding almost quantitatively the 1,3-disubstituted urea derivatives. Their subsequent cyclization provided the 1-substituted uracil and thymine compounds, in almost quantitative yield. (C) 2009 Elsevier Ltd. All rights reserved.
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