期刊
TETRAHEDRON
卷 65, 期 49, 页码 10149-10154出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.10.018
关键词
1,4-Dihydroquinolines; HA 14-1; Benzopyran; Anti-cancer; Bcl-2
资金
- CNRS
- MESR
- CSIR
- Tigue contre le Cancer' (Comite d'Ille et Vilaine)
A versatile strategy is described for the synthesis of new 2-amino-1,4-dihydroquinolines. it involved a Knoevenagel condensation of N-protected-2-amino-5-bromobenzaldehyde with ethylcyanoacetate, followed by a cyclization and protection of the NH group to afford the key intermediates 7 or 19. Then various 1,4 addition reactions have been performed to introduce substituents on the upper part of the 2-amino-1,4-dihydroquinolines. (C) 2009 Elsevier Ltd. All rights reserved.
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