Synthesis and photophysical properties of novel cyclonucleosides - substituent effects on fluorescence emission

An intramolecular [3+2]-cycloaddition between an azide and a disubstituted alkyne afforded a number of novel adenosine-derived cyclonucleosides, which exhibited fluorescence in the visible range. The synthesis and photophysical properties of these potential fluorescent probes are described. (c) 2008 Elsevier Ltd. All rights reserved.