期刊
TETRAHEDRON
卷 64, 期 8, 页码 1868-1878出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.11.094
关键词
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Four-membered heterophosphetes such as oxaphosphetes, thiaphosphetes, and azaphosphetes have long been considered desirable target molecules for organic chemists because of their interesting structural features. In spite of extensive investigation, only one azaphosphete and one thiaphosphete have been synthesized to date. In this paper, two possible conformers of these four-membered rings, as well as their open-ring phosphorane forms with a set of exocyclic substituents and a few ring heteroatoms were studied by molecular computations. The results suggested that the relative stability of these compounds is strongly dependent on the electronic effect of the exocyclic P-substituents. Three different types of exocyclic substituents X were recognized. However, only the strong electron-withdrawing substituents (X=F, CN, OCN, SCN) were able to stabilize the ring forms, providing the possibility to design stable heterophosphetes on the basis of the present computational results. (C) 2007 Elsevier Ltd. All rights reserved.
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