期刊
TETRAHEDRON
卷 64, 期 12, 页码 2864-2870出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.01.022
关键词
aldehydes; asymmetric catalysis; BINOL; hydrophosphonylation; Al(III)
A new bifunctional chiral AI(III) complex of BINOL derivative, which contained tert-amine at 3,3'-position of the BINOL, has been developed for the effective enantioselective hydrophosphonylation of aldehydes. A variety of aromatic, heteroaromatic, condensed-ring, alpha,beta-unsaturated, and aliphatic aldehydes were found to be suitable substrates for the reaction, and the desired alpha-hydroxy phosphonate were obtained in good to excellent yields (up to 99%) with moderate to good enantioselectivities (up to 87% ee) under mild conditions (at 0 degrees C). A possible catalytic cycle based on the experimental results was proposed. (C) 2008 Elsevier Ltd. All rights reserved.
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