期刊
TETRAHEDRON
卷 64, 期 51, 页码 11541-11548出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.10.035
关键词
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资金
- NIH
- CSIR
- INSA
Synthetic analogues of naturally occurring triterpenoids: glycyrrhetinic acid, arjunolic acid, and boswellic acids, by modification of A-ring with a cyano- and enone-functionality, have been reported. A novel method of synthesis of alpha-cyanoenones from isoxazoles is reported. Bioassays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cycotoxic activities associated with cyano-enones of boswellic acid and glycyrrhetinic acid. (C) 2008 Elsevier Ltd. All Fights reserved.
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