期刊
TETRAHEDRON
卷 64, 期 39, 页码 9280-9285出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.07.027
关键词
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资金
- XUNTA DE GALICIA [PGIDIT05PXIB26201PR, PR405 A 098/59-0]
- USC
- Xunta [2007/000145-0]
- FEDER
- Chemistry in High-Energy Microenvironments [WG 10]
2-Thiazolines are synthesized from carboxylic acids and 1,2-aminoalcohols in the presence of Lawesson's reagent Under solventless conditions. The developed method is Valid for either substituted or unsubstituted aminoalcohols and a wide variety of aromatic, heteroaromatic and aliphatic carboxylic acids: thus it constitutes a general synthetic method for these kinds of compounds. The role of Lawesson's reagent is dual: to transform the 1,2-aminoalcohol into 1,2-aminothiol and to activate its reaction with the carboxylic acid leading to the formation of a thiazoline ring, all in one pot. (C) 2008 Elsevier Ltd. All rights reserved.
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