期刊
TETRAHEDRON
卷 64, 期 16, 页码 3477-3482出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.02.022
关键词
organocatalyst; multi-component; 1,4-dihydropyridines; domino synthesis; solvent free
An organocatalysed protocol for one-pot synthesis of 1,4-dihydropyridines via three-component coupling of cinnamaldehyde, aniline and beta-keto esters under solvent free conditions at ambient temperature is reported. The reaction is generally very fast and the products are obtained in high yield. The catalytic activity of small organic molecules like amino acids (acidic, basic and neutral), ephedrine and cinchona alkaloids was studied. (c) 2008 Elsevier Ltd. All rights reserved.
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