期刊
TETRAHEDRON
卷 64, 期 22, 页码 5036-5043出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.03.068
关键词
beta-lactams; beta-amino acids; epoxidation; stereoselective synthesis
A simple synthetic approach has been developed for the regio- and diastereoselective synthesis of hydroxylated 2-aminocyclohexanecarboxylic acid stereoisomers from 1,4-cyclohexadiene by the reductive opening of appropriate epoxide intermediates derived from the corresponding bicyclic beta-lactams. This method has been extended to the synthesis of these hydroxylated p-amino acids in enantiomerically pure form. (C) 2008 Elsevier Ltd. All rights reserved.
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