4.4 Article

Tandem Michael addition/ylide olefination reaction for the synthesis of highly functionalized cyclohexadiene derivatives

期刊

TETRAHEDRON
卷 64, 期 35, 页码 8149-8154

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.06.048

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资金

  1. Natural Sciences Foundation of China
  2. Major State Basic Research Development Program [2006CB806105]
  3. Chinese Academy of Sciences
  4. Science and Technology Commission of Shanghai Municipality

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A tandem Michael addition/ylide olefination for the rapid creation of highly functionalized cyclohexadiene is developed. The tandem annulation reactions afford versatile cyclohexadienes in good to excellent isolated yields. This method has been successfully applied to the synthesis of three biologically active molecules. (C) 2008 Elsevier Ltd. All rights reserved.

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